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Linzess (Linaclotide) Approved for Relieving Chronic Constipation, IBS Symptoms

By August 31, 2012

Adults suffering from chronic constipation with no known cause, irritable bowel syndrome and IBS with constipation will have a new treatment option when Linzess (linaclotide) hits pharmacy shelves late this year.

IBS symptoms can be triggered by overeating or consuming certain foods.The U.S. Food and Drug Administration approved the drug developed by Ironwood Pharmaceuticals and Forest Laboratories on Aug. 30, 2012. The agency determined, however, that Linzess could not be considered safe and effective for children and teens younger than 17 years and asked the drugmakers to add a boxed warning to product labeling advising against prescribing the medication to younger patients. Animal studies on the use of Linzess in pediatric patients continue.

Patients should take a single Linzess capsule once each day, at least half an hour before eating their first meal. A higher dose of 290 micrograms is recommended for IBS sufferers, and a dose half that is recommended for people experiencing chronic constipation.

When announcing the drug's approval, Ironwood and Forest pointed particularly to the pain-relieving effects of Lizness.

The most common side effects experienced by patients taking Linzess during clinical trials were diarrhea, gas, stomach swelling and abdominal pain. In addition to the age warning, the drug's label states that Linzess should not be given to people whose intestines are blocked.

Here is the full prescribing information for Linzess.

Illustration courtesy of the National Institute of Diabetes and Digestive and Kidney Diseases

Comments

February 3, 2013 at 10:49 am
(1) gayle stevens says:

I have been taking kiznes for 1 wek nd already see the difference, Have not had any bad side effects.
This drug is a breakthrough because it DOES NOT contain a stimulant.

February 7, 2013 at 7:13 pm
(2) Lori says:

I just started it and my bowels are loose. I know that’s a side effect but does that stop after your body is used to is and your bowels maybe become normal? Just curious.

February 8, 2013 at 5:22 am
(3) pharmacy says:

Lori, Your question is best directed to your pharmacist or doctor. I’m neither and would never want to give you bad advice. — Ed

February 25, 2013 at 9:50 am
(4) Debby says:

I started taking Lizness about a week ago. I did have loose stool for a few days, but mine went away and I am very pleased with the results. My doctor also told me that I should not have dietary restrictions, so I am looking forward to that!

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